PittsburghV1, Main, Exploration, bibRecord, 001380

Serum Urate Levels and the Risk of Hip Fractures: Data from the Cardiovascular Health Study

Identifieur interne : 001380 ( Main/Exploration ); précédent : 001379; suivant : 001381

Serum Urate Levels and the Risk of Hip Fractures: Data from the Cardiovascular Health Study

Auteurs : Tapan Mehta [États-Unis] ; Petra Bůžková [États-Unis] ; Mark J. Sarnak [États-Unis] ; Michel Chonchol [États-Unis] ; Jane A. Cauley [États-Unis] ; Erin Wallace [États-Unis] ; Howard A. Fink [États-Unis] ; John Robbins ; Diana Jalal [États-Unis]

Source :

Metabolism: clinical and experimental [ 0026-0495 ] ; 2014.

RBID : PMC:4312534

Descripteurs français

KwdFr :
- Acide urique (sang), Enquêtes de santé, Estimation de Kaplan-Meier, Facteurs sexuels, Femelle, Fractures de la hanche (sang), Fractures de la hanche (épidémiologie), Humains, Indice de masse corporelle, Mâle, Oestrogénothérapie substitutive, Risque, Sujet âgé, Sujet âgé de 80 ans ou plus, États-Unis d'Amérique (épidémiologie), Études de cohortes, Études prospectives.
MESH :
- sang : Acide urique, Fractures de la hanche.
- épidémiologie : Fractures de la hanche, États-Unis d'Amérique.
- Enquêtes de santé, Estimation de Kaplan-Meier, Facteurs sexuels, Femelle, Humains, Indice de masse corporelle, Mâle, Oestrogénothérapie substitutive, Risque, Sujet âgé, Sujet âgé de 80 ans ou plus, Études de cohortes, Études prospectives.
Wicri :
- geographic : États-Unis.

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Body Mass Index, Cohort Studies, Estrogen Replacement Therapy, Female, Health Surveys, Hip Fractures (blood), Hip Fractures (epidemiology), Humans, Kaplan-Meier Estimate, Male, Prospective Studies, Risk, Sex Factors, United States (epidemiology), Uric Acid (blood).
MESH :
- chemical , blood : Uric Acid.
- geographic , epidemiology : United States.
- blood : Hip Fractures.
- epidemiology : Hip Fractures.
- Aged, Aged, 80 and over, Body Mass Index, Cohort Studies, Estrogen Replacement Therapy, Female, Health Surveys, Humans, Kaplan-Meier Estimate, Male, Prospective Studies, Risk, Sex Factors.

Abstract

Purpose

Uric acid inhibits vitamin D activation experimentally and higher serum urate levels are associated with higher parathyroid hormone levels in humans suggesting a link between uric acid and bone health. We hypothesized that hyperuricemia may increase the risk of fractures in older adults.

Methods

1963 men and 2729 women ≥ 65 years of age who participated in the Cardiovascular Health Study and had baseline serum urate levels were included in the study. The primary outcome was incident hip fracture, assessed prospectively through June, 2008 by inpatient and outpatient records. The analysis was stratified by sex apriori.

Results

There was a U- shaped relationship between serum urate levels and hip fractures in men. Men in the lowest and the highest urate quartiles (<4.88 and ≥6.88 mg/dL respectively) had a significantly higher rate of fractures in unadjusted analysis. However, upon multivariate adjustment, only the HR for hip fracture in highest quartile versus the reference remained significant (HR 1.9; 95% C.I. 1.1, 3.1; p value 0.02). High serum urate levels were not associated with hip fractures in women.

Conclusion

In this large prospective cohort of community-dwelling older adults, increased serum urate levels were associated with an increased risk of hip fractures in men. Further studies are needed to confirm these findings and to understand the mechanisms that underlie them.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312534

DOI: 10.1016/j.metabol.2014.11.006
PubMed: 25491429
PubMed Central: 4312534

Affiliations:

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Body Mass Index</term>
<term>Cohort Studies</term>
<term>Estrogen Replacement Therapy</term>
<term>Female</term>
<term>Health Surveys</term>
<term>Hip Fractures (blood)</term>
<term>Hip Fractures (epidemiology)</term>
<term>Humans</term>
<term>Kaplan-Meier Estimate</term>
<term>Male</term>
<term>Prospective Studies</term>
<term>Risk</term>
<term>Sex Factors</term>
<term>United States (epidemiology)</term>
<term>Uric Acid (blood)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Acide urique (sang)</term>
<term>Enquêtes de santé</term>
<term>Estimation de Kaplan-Meier</term>
<term>Facteurs sexuels</term>
<term>Femelle</term>
<term>Fractures de la hanche (sang)</term>
<term>Fractures de la hanche (épidémiologie)</term>
<term>Humains</term>
<term>Indice de masse corporelle</term>
<term>Mâle</term>
<term>Oestrogénothérapie substitutive</term>
<term>Risque</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>États-Unis d'Amérique (épidémiologie)</term>
<term>Études de cohortes</term>
<term>Études prospectives</term>
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<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>United States</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Hip Fractures</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Hip Fractures</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Acide urique</term>
<term>Fractures de la hanche</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Fractures de la hanche</term>
<term>États-Unis d'Amérique</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Body Mass Index</term>
<term>Cohort Studies</term>
<term>Estrogen Replacement Therapy</term>
<term>Female</term>
<term>Health Surveys</term>
<term>Humans</term>
<term>Kaplan-Meier Estimate</term>
<term>Male</term>
<term>Prospective Studies</term>
<term>Risk</term>
<term>Sex Factors</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Enquêtes de santé</term>
<term>Estimation de Kaplan-Meier</term>
<term>Facteurs sexuels</term>
<term>Femelle</term>
<term>Humains</term>
<term>Indice de masse corporelle</term>
<term>Mâle</term>
<term>Oestrogénothérapie substitutive</term>
<term>Risque</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Études de cohortes</term>
<term>Études prospectives</term>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title>
<p id="P1">Uric acid inhibits vitamin D activation experimentally and higher serum urate levels are associated with higher parathyroid hormone levels in humans suggesting a link between uric acid and bone health. We hypothesized that hyperuricemia may increase the risk of fractures in older adults.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">1963 men and 2729 women ≥ 65 years of age who participated in the Cardiovascular Health Study and had baseline serum urate levels were included in the study. The primary outcome was incident hip fracture, assessed prospectively through June, 2008 by inpatient and outpatient records. The analysis was stratified by sex <italic>apriori</italic>
.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">There was a U- shaped relationship between serum urate levels and hip fractures in men. Men in the lowest and the highest urate quartiles (<4.88 and ≥6.88 mg/dL respectively) had a significantly higher rate of fractures in unadjusted analysis. However, upon multivariate adjustment, only the HR for hip fracture in highest quartile versus the reference remained significant (HR 1.9; 95% C.I. 1.1, 3.1; p value 0.02). High serum urate levels were not associated with hip fractures in women.</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">In this large prospective cohort of community-dwelling older adults, increased serum urate levels were associated with an increased risk of hip fractures in men. Further studies are needed to confirm these findings and to understand the mechanisms that underlie them.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Colorado</li>
<li>Massachusetts</li>
<li>Minnesota</li>
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<li>Washington (État)</li>
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<tree><noCountry><name sortKey="Robbins, John" sort="Robbins, John" uniqKey="Robbins J" first="John" last="Robbins">John Robbins</name>
</noCountry>
<country name="États-Unis"><region name="Colorado"><name sortKey="Mehta, Tapan" sort="Mehta, Tapan" uniqKey="Mehta T" first="Tapan" last="Mehta">Tapan Mehta</name>
</region>
<name sortKey="Buzkova, Petra" sort="Buzkova, Petra" uniqKey="Buzkova P" first="Petra" last="Bůžková">Petra Bůžková</name>
<name sortKey="Cauley, Jane A" sort="Cauley, Jane A" uniqKey="Cauley J" first="Jane A." last="Cauley">Jane A. Cauley</name>
<name sortKey="Chonchol, Michel" sort="Chonchol, Michel" uniqKey="Chonchol M" first="Michel" last="Chonchol">Michel Chonchol</name>
<name sortKey="Fink, Howard A" sort="Fink, Howard A" uniqKey="Fink H" first="Howard A." last="Fink">Howard A. Fink</name>
<name sortKey="Jalal, Diana" sort="Jalal, Diana" uniqKey="Jalal D" first="Diana" last="Jalal">Diana Jalal</name>
<name sortKey="Sarnak, Mark J" sort="Sarnak, Mark J" uniqKey="Sarnak M" first="Mark J." last="Sarnak">Mark J. Sarnak</name>
<name sortKey="Wallace, Erin" sort="Wallace, Erin" uniqKey="Wallace E" first="Erin" last="Wallace">Erin Wallace</name>
</country>
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</record>

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Serum Urate Levels and the Risk of Hip Fractures: Data from the Cardiovascular Health Study

Serum Urate Levels and the Risk of Hip Fractures: Data from the Cardiovascular Health Study

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Abstract

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